Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
##挺好看的,實效性很強,跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高,每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適,很喜歡Doudna和Charpentier這種微妙的情感,既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題,好在後麵又拉迴來瞭
評分 評分 評分##"Great Inventions come from understanding basic science"
評分##挺好看的,實效性很強,跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高,每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適,很喜歡Doudna和Charpentier這種微妙的情感,既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題,好在後麵又拉迴來瞭
評分##很難評價,還是不打分瞭。作者很明顯是高質量傳記作者,他的能力已經在喬布斯傳當中充分展現瞭,在這本書當中更是展露無疑。science部分不難理解,但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者,自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角,去“客觀”地記錄CRISPR的曆史。很多事件的發生過程,作者明明有相當大的篇幅可以詳細地描述,反而實際上閃爍其詞,直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好,諷刺效果max,真是罵人於無形。 who tells the story還挺重要的,Lander在cell上的文章是這個目的,這本書同樣是這個目的。心潮澎湃大可不必,不過的確是一個勵誌故事。 作者以2020年諾貝爾化學奬得主Jennifer Doudna為主綫,講解瞭基因編輯技術的發展過程,以及對當下和未來的影響,並將眾多研究者飽滿地呈現齣來。科學知識與人物故事交織在一起,非常精彩的一本書。 作者從19世紀的達爾文和孟德爾,講到DNA結構被發現,再到人類基因組計劃。眾多...
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