The Code Breaker

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Walter Isaacson
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Simon & Schuster 2021-3-9 Hardcover 9781982115852

具体描述

Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

用户评价

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##除了学习科学知识 还借鉴得到成功科学家的品质 追求卓越注重合作然而又能严格管理自己的时间界限 生命科学的魅力 疫情初期紧锣密鼓的研究与疫苗开发 意外还有1984 vs. Brave New World这一对比重现 虽然有主POV CRISPR学术之争的叙述个人感觉尚且公正 希望能多收集一些行家线报实验室风云!

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##真是一本一言难尽的书,有点不伦不类的。如果是个传记,那么这是我读过的最失败的传记了,读之前对女主充满了崇拜,读完了几乎好感全无,觉得她好胜心过强。这本书是开始介绍珍妮弗·道德纳的背景求学经历以及如何开始研究RNA ,然后变成了一本CRISPR 科普,又陆续介绍了一群对CRISPR有贡献的科学家,然后开始八卦道德纳和张的CRISPR 专利战,然后又开始讨论基因改造的道德性,然后聊了聊RNA和新冠,最后以得诺贝尔奖结束。其实与其写成传记,不如学成一部纪实文学,从各方面客观的去讲述基因改造的发展更好一些。 让我想八卦的地方是,作者至少在2019年就开始参加一些活动了,应该是在最迟2019就开始着手这本书,那么后来的诺贝尔和新冠只是巧合的话,作者也太好运了。

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##其实应该叫The Code Breakers,除了Doudna and Charpentier, 作者对Zhang Feng的评价也很高,作者一直在强调对于基础科学研究的重要性,在十四五计划也有强调,期待各国能加大科研投入for a greater good

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##我并不很喜欢沃尔特.艾萨克森,以前看过其乔布斯传(中文),达芬奇传(有声书),总的来说,中规中矩。 然就本书而言,通过传记故事的方式,学到很多生化知识,体验象牙塔里的科研生活,还是很有收获。 最难忘怀的情节是他对Watson和其儿子的访问,可惜太短,毕竟是枝节。 人物传记,尽管是著名人物,要写出史诗感,张力十足也不容易。

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1、 根据我目前的认知,大部分生命活动的调控是精细而复杂的,并非敲除或改变一段序列就能产生显著效果。生命系统的复杂性也预示任意改造一段序列可能会有意外后果。此外,脱靶效应也会限制基因编辑技术的人体应用。所以,大规模的基因设计短时期内还只是个愿景,但早早开始考...  

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##很难评价,还是不打分了。作者很明显是高质量传记作者,他的能力已经在乔布斯传当中充分展现了,在这本书当中更是展露无疑。science部分不难理解,但是这个作者显然是使用语言的天才。他是Doudna的传记作者,自然是非常天生地需要站在她的那一边。他采用的并非第三方的视角,去“客观”地记录CRISPR的历史。很多事件的发生过程,作者明明有相当大的篇幅可以详细地描述,反而实际上闪烁其词,直接跳到事件发生的那个时刻。但是倒有足够的空间来全文引述一篇新年的email。那一段文字显然效果很好,讽刺效果max,真是骂人于无形。 who tells the story还挺重要的,Lander在cell上的文章是这个目的,这本书同样是这个目的。心潮澎湃大可不必,不过的确是一个励志故事。 作者以2020年诺贝尔化学奖得主Jennifer Doudna为主线,讲解了基因编辑技术的发展过程,以及对当下和未来的影响,并将众多研究者饱满地呈现出来。科学知识与人物故事交织在一起,非常精彩的一本书。 作者从19世纪的达尔文和孟德尔,讲到DNA结构被发现,再到人类基因组计划。众多...  

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