The Code Breaker

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Walter Isaacson
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Simon & Schuster 2021-3-9 Hardcover 9781982115852

具体描述

Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

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##roadtrip上听完了有声书 比预计的更有意思更drama crispr出来的时候 很多报道podcast采访 biotech/genes也hype很久了 但都知道了些皮毛 这本书听完才觉得真的懂了些 science确实是很competitive的field 特别是这些lab类的 发文章cycle还算快 就真的是分秒必争 同事之间的合作和竞争关系微妙 好奇如果有本从boston角度来讲(vs. Berkeley)会是怎么个态度 Isaacson很是细节之王 多少年前的事情 估计当事人都记不清楚了 他能写细致至极 feminism贯穿了整本书 最后几章讲gene editing moral的有点散

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I enjoyed reading the book. I appreciate that Walter has explained the concepts of biochemistry, a subject rather unfamiliar to me, in a both thorough and understandable way, covering a wide range of topics around CRISPR, including the history, the scientif...  

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##真是一本一言难尽的书,有点不伦不类的。如果是个传记,那么这是我读过的最失败的传记了,读之前对女主充满了崇拜,读完了几乎好感全无,觉得她好胜心过强。这本书是开始介绍珍妮弗·道德纳的背景求学经历以及如何开始研究RNA ,然后变成了一本CRISPR 科普,又陆续介绍了一群对CRISPR有贡献的科学家,然后开始八卦道德纳和张的CRISPR 专利战,然后又开始讨论基因改造的道德性,然后聊了聊RNA和新冠,最后以得诺贝尔奖结束。其实与其写成传记,不如学成一部纪实文学,从各方面客观的去讲述基因改造的发展更好一些。 让我想八卦的地方是,作者至少在2019年就开始参加一些活动了,应该是在最迟2019就开始着手这本书,那么后来的诺贝尔和新冠只是巧合的话,作者也太好运了。

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