細胞興奮性、神經係統的基因錶達與調控（導讀版）（影印版） [Encyclopedia of Neuroscience:Cellular Excitability,Gene Expression and 下載 mobi epub pdf 電子書 2025

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☆☆☆☆☆

斯奎爾（Larry R.Squire） 著

齣版社： 科學齣版社

ISBN：9787030280831

版次：1

商品編碼：10320797

包裝：精裝

叢書名： 神經科學百科全書7

外文名稱：Encyclopedia of Neuroscience:Cellular Excitability,Gene Expression and Regulation in the Nervous System

內容簡介

　　 此百科全書篇幅巨大，為所有神經科學百科全書之首。書中覆蓋瞭神經科學全部主要領域，由來自世界各地的2400多位專傢撰稿人閤力打造。每個詞條在收入書中之前均經過顧問委員會的同行評議，詞條中均含有詞匯錶、引言、參考文獻和豐富的交叉參考內容。其內容平易，本科生即可讀懂；而深度和廣度獨有，足可滿足專傢學者的需要。主編LarryR.Squire為美國神經科學學會前主席，暢銷教科書《基礎神經科學》（FundamentalNeuroscience）的策劃人與主編。此為本套圖書的第七冊，內容包括細胞興奮性，和神經係統的基因錶達與調控。

目錄

Action Potential Initiation and Conduction in Axons
Calcium and Signal Transduction
Calcium Channel and Calcium-Activated Potassium Channel Coupling
Calcium Channel Subtypes Involved in Neurotransmitter Release
Calcium Channels
Calcium Channels and SNARE Proteins
Calcium Homeostasis in Glia
Calcium Waves in Glia
Calcium Waves Purinergic Regulation
Cotransmission
Cyclic Nucleotide-Gated and Hyperpolarization-Activated Channels
Dendritic Signal Integration
Dorsal Root Ganglion Neurons
Glial Influence on Synaptic Transmission
Glutamate Receptor Clusters Narp， EphB2 Receptor， Stargazin
Glutamate Regulation of Dendritic Spine Form and Function
Hair Cells Sensory Transduction
Hodgkin-Huxley Models
Information Coding
Inwardly Rectifying Potassium Channels
Ion Channel Localization in Axons
Ion Channel Localization in Cell Bodies and Dendrites
Ionic Channels in Glia
Large Conductance Calcium-Activated Potassium Channels
Myelin Molecular Architecture of CNS and PNS Myelin Sheath
Neuromodulation of Calcium Channels
Neuromodulation of Sodium Channels
Neuronal Pacemaking ，
Neutrotransmission and Neuromodulation Acetylcholine
Potassium Channel Regulation
Schwann Cells and Axon Relationship
Sodium Channels
Spike-Timing-Dependent Plasticity （STDP）
Spine Plasticity
Synaptic Transmission Models
Transient Receptor Potential （TRP） Channels
Two-P-Domain （K2p） Potassium Channels Leak Conductance Regulators of Excitability
Ultrastructural Analysis of Spine Plasticity
Voltage Gated Potassium Channels Structure and Function of Kvl to Kv9 Subfamilies
Voltage-Gated Calcium Channels
Voltage-Gated Potassium Channels （Kv10-Kv12）
神經係統的基因錶達與調控
Alternative Splicing in the Nervous System
Alzheimers Disease Molecular Genetics
Alzheimers Disease Transgenic Mouse Models
Aversive Emotions Genetic Mechanisms of Serotonin
BAC Transgenesis Cell-Type Specific Expression in the Nervous System
Circadian Gene Expression in the Suprachiasmatic Nucleus
Clock Gene Regulation of Endocrine Function
Clock Genes and Metabolic Regulation
Decoding Neuron Transcriptome by SAGE
Dendrites Localized Translation
Gene Expression Dysregulation in CNS Pathophysiology
Gene Expression in Normal Aging Brain
Gene Expression in the Evolution of the Human Brain
Gene Expression Regulation Activity-Dependent
Gene Expression Regulation Chromatin Modification in the CNS
Gene Expression Regulation Steroid Hormone Effects
Gene Therapy Direct Viral Delivery
Gene Therapy Genetically Modified Cells
Genetic Influence on CNS Gene Expression Impact on Behavior
Genetic Regulation of Circadian Rhythms in Drosophila
Genomic Disorder and Gene Expression in the Developing CNS
Genomics of Brain Aging Apolipoprotein E
Genomics of Brain Aging Nuclear and Mitochondrial Genomes
Genomics of Brain Aging Twin Studies
Hippocampus Molecular Anatomy
Hox Genes Expression
Microarray use for the Analysis of the CNS
Molecular Anatomy of the Mammalian Brain
Neuromuscular Junction Neuronal Regulation of Gene Transcription at the Vertebrate
Olfactory Insights from Transcriptional Profiling
Pain and Genes
Plasticity， and Activity-Dependent Regulation of Gene Expression
Psychiatric Disorders Functional Genomics
Psychiatric Genomics and Expression Profiling
Single Cell Genomic DNA Analysis
Sleep and Sleep States Gene Expression
Sox Gene Expression
Stress Response Genetic Consequences
Thyroid Hormone and Transcriptional Regulation in the CNS
Transcription and Reward Systems
Transcription Control and the Circadian Clock
Transcription Factors in Synaptic Plasticity and Learning and Memory
Transcriptional Networks and the Spinal Cord
Transcriptional Silencing
VelociGene and VelociMouse High-Throughput Approaches for Generating Targeted Mutations in Mice on a Genome-Wide Scale
原書詞條中英對照錶

精彩書摘

Voltage-gated potassium channels have K+-selectivepores that are opened by membrane depolarization.This opening allows the movement of K+ ions acrossthe plasma membrane and the generation of K+ cur-rents that tend to repolarize the membrane towardthe equilibrium potential for K+ （EK）. Voltage-gatedpotassium channels contribute widely to the electricalproperties of neurons. They influence subthresholdproperties， including the resting potential and mem-brane resistance. They influence the amplitude andfrequency of subthreshold oscillations， the responsive-ness of the cell to synaptic inputs， and the probabilityof spike generation. They help shape postsynapticpotentials， and they are the main determinants of therepolarization of the action potential governing spikeshape and frequency. Their voltage-dependent activityensures a non-ohmic current-voltage relationship，which thereby enables the channels to contribute tothe nonlinear properties of neurons. Voltage-gatedpotassium channels have similar functions in otherexcitable cells， including all varieties of muscle. In non-excitable cells， they contribute to the resting potentialand to the regulation of Ca2+ entry and secretion. Voltage-gated K+ channels differ dramatically intheir kinetic and voltage-dependent properties aswell as their cellular and subcellular distributions.This diversity is a main contributor to the varied elec-trical properties of neuronal populations throughoutthe nervous system. Thus， understanding the input-output relationship of neuronal elements demands thecontinued effort to study the properties and localiza-tion of these channels and analyze their physiologicalroles in native membranes.

前言/序言

　　20世紀中葉以來，關於神經係統的研究從以往生物與心理學研究的邊緣地位躍升，成為神經科學這一交叉學科。這一新學科將生物化學、細胞生物學、解剖學、生理學、心理學、神經病學、精神病學等具有不同背景的科學傢與臨床醫生們聯係起來，研究令人激動的腦的秘密。他們專注於探索神經元的功能機製，澄清行為與認知的神經基礎，瞭解神經係統疾病。1969年神經科學學會的創建大大促進瞭該學科的發展，如今該學會已經擁有近37 000名會員。第一個針對神經科學的學術培訓項目建立於醫學院（1965年加州大學聖迭戈分校建立神經科學係，1966年哈佛大學建立神經生物學係）。第一個本科生培訓項目於1972年建立於Amherst學院和Oberlin學院，後者培養瞭諾貝爾奬獲得者：Roger Sperry和三位神經科學會會長。時至今日，全世界已經有超過300個神經科學係或相應的培養項目。
　　《神經科學百科全書》旨在將本學科豐富多元的內容條理化並仔細介紹，從而推動不同學術分支之間的溝通，提供權威的信息來源。該書麵嚮較為廣泛的讀者群體，既包括初入神經科學研究的學生，也包括尋求特定專題知識的普通讀者。無論是神經科學傢，還是正在學習神經科學的本科生和研究生，或生命科學領域的教師、科普作傢，都會從該參考書中獲益。
　　《神經科學百科全書》的第一版，也是該學科的第一本詳盡的參考書，於1987年在George Adelman卓有成效的領導下齣版；該版本分為兩捲，共700多個條目。本書的第二版由George Adelman和Barry Smith主編，包括超過800個條目，於1999年分兩捲齣版，同時配發瞭光盤版。2004年的第三版僅以電子版本發行。
　　本次齣版的版本包括近1500個條目，全書在Science Direct網站上發行，讀者可以注冊登錄閱讀。主編小組在神經科學中劃分齣46個主要領域，並邀請各個領域的專傢擔任副主編，由他們組織該領域的內容。每位副主編再邀請30~40位作者準備各個專題條目，這些專題將努力涵蓋該領域的所有內容。許多專題作者都是該領域享有盛譽的領導者。這使得該書成為當今神經科學學科的匯編，其中囊括瞭最重要的研究、最有力的研究工具、最有潛力的應用。
　　許多條目本身就是一篇自成一體的獨立綜述。同時，在結論部分又有大量的交叉引用，它們可以將讀者引入其他相關的條目。此書主體上以字母順序組織所有條目。此外，詳盡的主題分類又可以幫助讀者找到相關的專題，以瞭解本學科的結構。
　　雖然沒有一本神經科學的參考書能夠囊括大腦研究每一個值得注意的想法和成果，主編們仍希望本書能夠成為一本既翔實又具指導意義的、反映當代神經科學研究的匯編。神經科學還在不斷發展嚮前，如果本書能夠在徵服神經係統疾病，和瞭解腦、思維及我們自身的徵程中發揮作用，它就獲得瞭成功。

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